dc.contributor.author | Kosztin, Ioan | eng |
dc.contributor.author | Schulterr, K. (Klaus) | eng |
dc.date.issued | 2004 | eng |
dc.description | URL:http://link.aps.org/doi/10.1103/PhysRevLett.93.238102
DOI:10.1103/PhysRevLett.93.238102 | eng |
dc.description.abstract | Channel proteins that selectively conduct molecules across cell membranes often exhibit an asymmetric structure. By means of a stochastic model, we argue that channel asymmetry in the presence of nonequilibrium fluctuations, fueled by the cell's metabolism as observed recently, can dramatically influence the transport through such channels by a ratchetlike mechanism. For an aquaglyceroporin that conducts water and glycerol, we show that a previously determined asymmetric glycerol potential leads to enhanced inward transport of glycerol, but for unfavorably high glycerol concentrations also to enhanced outward transport that protects a cell against poisoning. | eng |
dc.description.sponsorship | We acknowledge financial support from the
University of Missouri Research Board, the Institute for Theoretical Sciences, and the Department of Energy (DOE Contract No. W-7405-ENG-36) for I. K., and the National Institutes of Health (NIH 1-R01-GM067887-01) for K. S. | eng |
dc.identifier.citation | Phys. Rev. Lett. 93, 238102 (2004) | eng |
dc.identifier.issn | 0031-9007 | eng |
dc.identifier.uri | http://hdl.handle.net/10355/9075 | eng |
dc.language | English | eng |
dc.publisher | American Physical Society | eng |
dc.relation.ispartofcollection | University of Missouri--Columbia. College of Arts and Sciences. Department of Physics and Astronomy. Physics and Astronomy publications | eng |
dc.subject | fluctuation phenomena | eng |
dc.subject.lcsh | Biological transport, Active | eng |
dc.subject.lcsh | Ion channels | eng |
dc.subject.lcsh | Stochastic analysis | eng |
dc.subject.lcsh | Brownian motion processes | eng |
dc.title | Fluctuation-Driven Molecular Transport Through an Asymmetric Membrane Channel | eng |
dc.type | Article | eng |