Rare case of hemophagocytic lymphohistiocytosis secondary to tularemia

Abstract

"Hemophagocytic lymphohistiocytosis (HLH) is a rare, life-threatening syndrome of excessive immune activation that can be acquired genetically or sporadically. It is triggered by events that disrupt immune function and has a variable presentation that has a median survival of 2 months without prompt treatment. Tularemia is a highly infectious zoonotic illness caused by Francisella tularensis that most commonly results in ulcero-glandular disease. We have been unable to find previously documented cases of HLH secondary to tularemia."--Introduction.