Effects of Flavonoids on Collagen Biostability, Remineralization and Long Term Durability of Natural and Denatured Dentin
Date
2022Metadata
[+] Show full item recordAbstract
Collagen biostability in the resin dentin interface determines the longevity of dental composite restorations. Maintaining this biostability becomes even more challenging in the altered and denatured substrate of caries affected dentin (CAD). In this study two strategies, the use of crosslinker and remineralizing agents were evaluated for improving collagen biostability in natural and CAD. To understand the effect of these strategies three aims were addressed: 1) characterizing the effects of natural flavonoids theaflavins (TF) and Cranberry (CR) in crosslinking natural and denatured dentin collagen; 2) evaluating the effects of remineralizing agents on natural and denatured dentin collagen in presence of a crosslinker and 3) evaluating the effect of dual- functional etchants on longevity of dental composite restorations in natural and CAD. Results of these studies were as follows. First the crosslinking interaction of natural flavonoids with dentin collagen created alterations in collagen structure that significantly improved the biostability of natural and denatured dentin collagen. Second the use of remineralizing agents with natural flavonoids crosslinker CR reduced the time required for remineralization and provided a sturdy collagen scaffold for remineralization. Third, dual-functional etchants used for a clinically feasible time of 30 seconds were able to improve the longevity of resin dentin bonds created in natural or CAD. These results showed that TF and CR are efficient crosslinkers with the ability to protect dentin collagen against enzymatic degradation within 30 seconds treatment time. Along with improving remineralization potential, these crosslinkers are efficient dual functional etchants which can improve the longevity of resin dentin bonds.
Table of Contents
Introduction -- Background -- The effects of flavonoids on structural, mechanical properties and biostability of natural and denatured dentin collagen -- The effects of flavonoids on remineralization of natural and denatured dentin collagen -- The effects of dual-functional etchants on durability of resin dentin bonds in natural and caries affected dentin -- Conclusions
Degree
Ph.D. (Doctor of Philosophy)