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dc.contributor.authorBleacher, Heathereng
dc.contributor.authorKoerperich, Lindsayeng
dc.contributor.authorMalam, Naomieng
dc.contributor.authorDeSanto, Kristeneng
dc.date.issued2022-07eng
dc.description.abstractQ: Are antipsychotics effective adjunctive Tx for patients with moderate-to-severe depression? Evidence-based answer: YES. Augmentation with second-generation antipsychotics, especially aripiprazole and quetiapine, appears to be effective in patients with moderate-to-severe depression who have had a suboptimal response to a selective serotonin reuptake inhibitor or a serotonin-norepinephrine reuptake inhibitor (strength of recommendation [SOR]: A, based on a systematic review of randomized controlled trials [RCTs] and an individual RCT). Augmenting antidepressant therapy with cariprazine, ziprasidone, or olanzapine also appears to improve depressive symptoms over the short term. All antipsychotics studied carried an increased likelihood of adverse effects that could lead to discontinuation (SOR: A, based on a systematic review of RCTs).eng
dc.description.bibrefIncludes bibliographical referenceseng
dc.description.statementofresponsibilityHeather Bleacher, MD, MPH; Lindsay Koerperich, MD; Naomi Malam, MD, MSPH (University of Colorado Family Medicine Residency, Denver) Kristen DeSanto, MSLS, MS, RD (University of Colorado Health Sciences Library, Denver)eng
dc.format.extent3 pageseng
dc.identifier.citationThe journal of family practice 71 (6) 2022 E13-E15eng
dc.identifier.urihttps://hdl.handle.net/10355/91363
dc.languageEnglisheng
dc.publisherFamily Physicians Inquiries Networkeng
dc.relation.ispartofcollectionClinical Inquiries, 2022 (MU)eng
dc.relation.ispartofcommunityUniversity of Missouri--Columbia. School of Medicine. Department of Family and Community Medicine. Family Physicians Inquiries Networkeng
dc.rightsOpenAccess.eng
dc.rights.licenseThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License.eng
dc.titleAre antipsychotics effective adjunctive Tx for patients with moderate-to-severe depression?eng
dc.typeArticleeng


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