Shared more. Cited more. Safe forever.
    • advanced search
    • submit works
    • about
    • help
    • contact us
    • login
    View Item 
    •   MOspace Home
    • University of Missouri-Columbia
    • Health Sciences Research Day (MU)
    • 2010 Health Sciences Research Day (MU)
    • View Item
    •   MOspace Home
    • University of Missouri-Columbia
    • Health Sciences Research Day (MU)
    • 2010 Health Sciences Research Day (MU)
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.
    advanced searchsubmit worksabouthelpcontact us

    Browse

    All of MOspaceCommunities & CollectionsDate IssuedAuthor/ContributorTitleIdentifierThesis DepartmentThesis AdvisorThesis SemesterThis CollectionDate IssuedAuthor/ContributorTitleIdentifierThesis DepartmentThesis AdvisorThesis Semester

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular AuthorsStatistics by Referrer

    Acute (binge) administration of ethanol causes histone H3 phosphorylation at SER-10, SER-28 & gene expression in rat liver in vivo [abstract]

    James, Taryn
    View/Open
    [PDF] AcuteBingeAdministrationEthanol.pdf (223.3Kb)
    Date
    2010
    Contributor
    University of Missouri--Columbia. School of Medicine
    Format
    Abstract
    Metadata
    [+] Show full item record
    Abstract
    Epigenetic histone modification is emerging as a critical player in the cellular actions of ethanol. In this study we have examined the effect of ethanol on histone H3 phosphorylation in vivo using an acute model. Twelve week old male Sprague Dawley rats were intraperitoneally administered either ethanol in a 32% solution, or water as a control, to determine the effect of ethanol on histone H3 phosphorylation at 1h using 1.75g, 3.5g or 5g of ethanol/ kg body weight. Significant increases in the histone H3 phosphorylation at serine-10 and serine-28 occurred at 1.75 and 3.5 grams of ethanol; with negligible change at the higher 5 gram dose. Thus, histone phosphorylation occurred at lower blood alcohol levels but not at higher levels in vivo. There was induction of immediate early genes, c-Fos, c-Jun and MKP-1 that accompanied the changes in histone phosphorylation. Taken together, it is concluded that acute ethanol causes site specific serine phosphorylation in histone H3 at patho-physiological concentrations and modulates expression of genes. These data are relevant to the identification of "early" molecular processes involved in the binge induced liver injury. Supported by NIAAA grant AA16347.
    URI
    http://hdl.handle.net/10355/9152
    Rights
    OpenAccess.
    This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License.
    Collections
    • 2010 Health Sciences Research Day (MU)

    Send Feedback
    hosted by University of Missouri Library Systems
     

     


    Send Feedback
    hosted by University of Missouri Library Systems