Affects of the inhibition of microRNA regulatory machinery in lymphoma cells [abstract]
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MicroRNAs influence many processes such as development, cell proliferation and differentiation and cell death. MicroRNAs are intergrated into a complex called RISC with Argonatue proteins to target mRNAs. Recent studies are finding microRNAs to have a significant role in the pathogenesis of cancer cells. The hypothesis is inhibiting the microRNA regulatory machinery in lymphoma cell lines (CLL, ALL, and follicular lymphoma) will lead to global alterations in regions of active chromatin.