Browsing 2022 MU Dissertations - Freely available online by Thesis Department "Biomedical sciences (MU)"
Now showing items 1-5 of 5
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Mechanistic understanding and potential targets for mustard gas keratopathy
(University of Missouri--Columbia, 2022)Sulfur mustard gas (SM), a vesicating and alkylating agent, has been used as a warfare agent since World War I and recently in Syria. SM exposure causes severe corneal injury, pain, and irreversible blindness. The cornea ... -
Mineralocorticoid receptor involvement in vascular dysfunction associated with vascular injury
(University of Missouri--Columbia, 2022)Mineralocorticoid receptor (MR) signaling has recently been implicated in cardiovascular dysfunction associated vascular injury. Specifically, MR blockade has been shown to treat coronary microvascular dysfunction in obesity ... -
The role of Cdc42 Rho GTPase in the cystic fibrosis intestinal epithelial barrier
(University of Missouri--Columbia, 2022)Cystic fibrosis (CF) is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. People with CF and CF mouse models experience increased intestinal permeability, but the molecular mechanisms ... -
The role of creatine supplementation and mTORC1 signaling in ameliorating cognitive deficiency in a neuroinflammatory rat model
(University of Missouri--Columbia, 2022)Mild cognitive impairment (MCI) was defined as a boundary area between cognitive function of natural aging and dementia. Early studies have suggested that MCI could be a therapeutic window for prevention of dementia, given ... -
Ventricle-specific fibrotic cardiac remodeling in the progression of heart failure with preserved ejection fraction
(University of Missouri--Columbia, 2022)Heart failure with preserved ejection fraction (HFpEF) is currently the most prominent form of heart failure (HF). Despite the rising prevalence over the last few years, the pathogenesis of this disease is still unknown. ...