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    Ang II contributes proximal tubule remodeling in transgenic Ren2 rats [abstract]

    Panfili, Zachary
    Habibi, Javad, 1947-
    Hayden, Melvin
    Nistala, Ravi
    Parrish, Alan
    Sowers, James R. (James Russell), 1942-
    Tilmon, Roger
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    [PDF] AngIIContributesProximal.pdf (223.9Kb)
    Date
    2010
    Contributor
    University of Missouri--Columbia. School of Medicine
    Format
    Abstract
    Metadata
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    Abstract
    Activation of the renin-angiotensin system (RAS) and subsequent elevations of tissue angiotensin (Ang) II contribute to the development of proteinuria and progressive kidney disease. Recent work suggests that proximal tubule injury contributes to development of proteinuria in addition to glomerular contributions. Thereby, the aim of this study was to determine the impact that Ang II has on renal proximal tubular cell (PTC) function in a transgenic rodent model of hypertension and nephropathy, the transgenic TG(mRen2)27 rat.
    URI
    http://hdl.handle.net/10355/9158
    Rights
    OpenAccess.
    This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License.
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