Ang II contributes proximal tubule remodeling in transgenic Ren2 rats [abstract]

Abstract

Activation of the renin-angiotensin system (RAS) and subsequent elevations of tissue angiotensin (Ang) II contribute to the development of proteinuria and progressive kidney disease. Recent work suggests that proximal tubule injury contributes to development of proteinuria in addition to glomerular contributions. Thereby, the aim of this study was to determine the impact that Ang II has on renal proximal tubular cell (PTC) function in a transgenic rodent model of hypertension and nephropathy, the transgenic TG(mRen2)27 rat.