Yersinia pestis YopJ and its impact on innate immunity
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Yersinia pestis is one of the most virulent pathogens known to man, with the most impactful epidemics in human history. As the causative agent for the plague, Y. pestis has demonstrated its propensity to ravage through animal and human populations. As a zoonotic disease that can confer transmission between different species of mammals, this further illustrates the importance of plague research. Today, plague still has a foothold in several countries such as India and Madagascar. Worldwide outbreaks led to its ranking as number 5 in emerging zoonotic diseases by the Centers for Disease Control in 2019. Despite the gratuitous devastation it has displayed worldwide, Y. pestis has piqued interest in use for bioterrorism from multiple superpowers. Given the exhibition of its reach in the 14th century, and its conserved methods of pathogenesis in other pathogens, plague studies demonstrate a broader impact in elucidating the mechanisms of infectious diseases.
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Ph. D.