Beta cell dysfunction, oxidative stress and S6K1 activation in pancreas in the Zucker obese rat model [abstract]

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Beta cell dysfunction, oxidative stress and S6K1 activation in pancreas in the Zucker obese rat model [abstract]

Please use this identifier to cite or link to this item: http://hdl.handle.net/10355/9164

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Title: Beta cell dysfunction, oxidative stress and S6K1 activation in pancreas in the Zucker obese rat model [abstract]
Author: Krueger, Charles; Lastra, Guido; Dhuper, Sonal
Keywords: obesity
pancreatic insulin
Date: 2010-11-11
Abstract: Insulin resistance and beta cell dysfunction are leading components in the pathogenesis of type 2 diabetes mellitus. Over-nutrition leads to activation of the mTOR/S6K1. S6K1 activation leads to serine phosphorylation of IRS1, triggering its proteosomal degradation and interfering with insulin metabolic signaling. We investigated the role of over-nutrition on S6K1 pathway, oxidative stress and insulin signaling in the Zucker Obese (ZO) rat, which displays severe obesity, systemic insulin resistance, glucose intolerance, and hypertension.
URI: http://hdl.handle.net/10355/9164

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