Beta cell dysfunction, oxidative stress and S6K1 activation in pancreas in the Zucker obese rat model [abstract]
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Insulin resistance and beta cell dysfunction are leading components in the pathogenesis of type 2 diabetes mellitus. Over-nutrition leads to activation of the mTOR/S6K1. S6K1 activation leads to serine phosphorylation of IRS1, triggering its proteosomal degradation and interfering with insulin metabolic signaling. We investigated the role of over-nutrition on S6K1 pathway, oxidative stress and insulin signaling in the Zucker Obese (ZO) rat, which displays severe obesity, systemic insulin resistance, glucose intolerance, and hypertension.
2010 Health Sciences Research Day (MU)