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    Beta cell dysfunction, oxidative stress and S6K1 activation in pancreas in the Zucker obese rat model [abstract]

    Krueger, Charles
    Lastra, Guido
    Dhuper, Sonal
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    [PDF] BetaCellDysfunction.pdf (224.9Kb)
    Date
    2010
    Contributor
    University of Missouri--Columbia. School of Medicine
    Format
    Abstract
    Metadata
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    Abstract
    Insulin resistance and beta cell dysfunction are leading components in the pathogenesis of type 2 diabetes mellitus. Over-nutrition leads to activation of the mTOR/S6K1. S6K1 activation leads to serine phosphorylation of IRS1, triggering its proteosomal degradation and interfering with insulin metabolic signaling. We investigated the role of over-nutrition on S6K1 pathway, oxidative stress and insulin signaling in the Zucker Obese (ZO) rat, which displays severe obesity, systemic insulin resistance, glucose intolerance, and hypertension.
    URI
    http://hdl.handle.net/10355/9164
    Rights
    OpenAccess.
    This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License.
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