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Chronic ethanol exposure alters epigenetic mechanism in the basal forebrain [abstract]

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http://hdl.handle.net/10355/9172
dc.contributor.advisorThakkar, Mahesheng
dc.contributor.authorLodhi, Shafieng
dc.contributor.authorSharma, Rishieng
dc.contributor.authordeRoode, Davideng
dc.contributor.authorForman, Suzanneeng
dc.contributor.corporatenameUniversity of Missouri--Columbia. School of Medicineeng
dc.contributor.meetingnameHealth Sciences Research Day (2010 : University of Missouri)eng
dc.date.issued2010eng
dc.description.abstractOne of the most commonly observed characteristics of alcohol withdrawal is insomnia. Importantly, there is a strong association between insomnia and relapse to alcoholism. In a recent study, we have shown that insomnia in ethanol dependent rats may result from reduced gene expression of proteins responsible for adenosine release and transmission in the basal forebrain (BF). Histone acetylation is an epigenetic phenomenon that promotes gene expression. Does ethanol dependence alter histone acetylation in the BF and affect gene expression?eng
dc.format.extent1 pageeng
dc.identifier.urihttp://hdl.handle.net/10355/9172
dc.languageEnglisheng
dc.relation.ispartofcommunityUniversity of Missouri--Columbia. Health Sciences Research Dayeng
dc.rightsOpenAccess.eng
dc.rights.licenseThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License.eng
dc.subjectalcohol consumptioneng
dc.subjectsleep disordereng
dc.subject.FASTAlcohol withdrawal syndromeeng
dc.subject.FASTInsomniaeng
dc.subject.FASTEthanoleng
dc.subject.FASTRats as laboratory animalseng
dc.titleChronic ethanol exposure alters epigenetic mechanism in the basal forebrain [abstract]eng
dc.typeAbstracteng


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