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    • University of Missouri-Columbia
    • Graduate School - MU Theses and Dissertations (MU)
    • Theses and Dissertations (MU)
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    • 2008 Dissertations (MU)
    • 2008 MU dissertations - Access restricted to MU
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    Development of novel bionanocomposite scaffolds

    Deeken, Corey Renee
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    [PDF] short.pdf (25.12Kb)
    [PDF] research.pdf (9.246Mb)
    Date
    2008
    Format
    Thesis
    Metadata
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    Abstract
    [ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] The development of three novel bionanocomposite scaffolds is presented in this dissertation. These scaffold materials are comprised of amine-functionalized nanomaterials crosslinked to the extracellular matrix (ECM) component of a porcine diaphragm tendon. On its own, the ECM is an ideal scaffold material with the structure and properties needed to support cellular attachment and tissue ingrowth. Nanomaterials were utilized to improve the physicochemical properties of the ECM while also influencing cellular behavior through a nanostructured surface. A full characterization of the bionanocomposite scaffolds was accomplished through a variety of common materials characterization techniques. Several biocompatibility studies were also performed including both in vitro studies using flow cytometry and bioreactors, as well as in vivo studies involving rodent and porcine models. The results of these studies indicated that the bionanocomposite scaffolds possessed appropriate properties for soft tissue repair applications. Future studies will be performed with the goal of further developing these materials into commercial products.
    URI
    https://hdl.handle.net/10355/9180
    https://doi.org/10.32469/10355/9180
    Degree
    Ph. D.
    Thesis Department
    Biological engineering (MU)
    Rights
    Access is limited to the campus of the University of Missouri--Columbia.
    Collections
    • 2008 MU dissertations - Access restricted to MU
    • Biological Engineering electronic theses and dissertations - CAFNR (MU)
    • Biological Engineering electronic theses and dissertations - Engineering (MU)

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