The effects of toll-like receptor ligand-activated dendritic cells on human CD4⁺T cell responses

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The effects of toll-like receptor ligand-activated dendritic cells on human CD4⁺T cell responses

Please use this identifier to cite or link to this item: http://hdl.handle.net/10355/9194

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Title: The effects of toll-like receptor ligand-activated dendritic cells on human CD4⁺T cell responses
Author: Benwell, Risa Kitawaki, 1977-
Date: 2008
Publisher: University of Missouri--Columbia
Abstract: Dendritic cells (DCs) play an important role as a link between innate and adaptive immunity through their abilities to detect infection and to prime naïve T cells (signal 1 and 2). They not only activate naïve T cells, but also direct differentiation of CD4+ T cells to induce appropriate immune responses against pathogens via cytokine production (signal 3). In this study, human monocyte-derived dendritic cells (moDCs) as a model for myeloid DCs were activated in vitro with an array of Toll-like receptor (TLR) ligands derived from or mimicking various pathogens, to determine their cytokine profiles, as well as the ability of these differentially TLR ligand-activated DCs to induce differentiation of naïve CD4+ T cells. moDCs activated with a viral TLR ligand (TLR3 ligand) induced more heavily skewed Th1 responses, whereas bacterial TLR ligand (TLR1/2, 4 and 5 ligand)-activated moDCs induced more balanced Th1/Th2/Th17 responses in CD4+ T cells. Unexpectedly, moDCs activated with another viral TLR ligand (TLR7/8 ligand) also induced more balanced Th1/Th2/Th17 CD4+ T cell responses. These results provide a framework for the use of these TLR ligands in tailoring T cell responses in vaccines and other immunotherapeutic approaches.
URI: http://hdl.handle.net/10355/9194
Other Identifiers: BenwellR-100710-D11399

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