Development of biospecimen sample preparation techniques for molecular imaging using ultra-high resolution mass spectrometry [abstract]
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Matrix assisted laser desorption ionization (MALDI) imaging is a technique which analyzes and maps the distribution of molecules in two-dimensional biospecimens, such as histological tissue sections. To-date, the classifications of molecules imaged using this technique is nearly comprehensive to those found in all tissues and include proteins, lipids, peptides, carbohydrates, nucleic acids, drugs, metabolites and other molecules. Using an imaging mass spectrometer, two-dimensional images may be produced by “staining” an optical image with an overlay of the distributions of multiple specific mass signals, elucidating the molecular architecture within the context of a biospecimen. In the future, MALDI imaging may revolutionize early-state disease diagnosis, biomarker discovery, drug development and personalized medicine.