Don't be such a baby! or the effects of the environment and T cells on neonatal immunity [abstract]

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Don't be such a baby! or the effects of the environment and T cells on neonatal immunity [abstract]

Please use this identifier to cite or link to this item: http://hdl.handle.net/10355/9205

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Title: Don't be such a baby! or the effects of the environment and T cells on neonatal immunity [abstract]
Author: Hoeman, Christine
Keywords: immune system
environmental factors
Date: 2010-11-11
Abstract: It is known that neonates are highly susceptible to microbial infections and allergic reactions. This susceptibility is due to a lack of Th1 cells and an excess of its Th2 counterparts. However, the mechanism underlying this Th1/Th2 imbalance has not been clearly elucidated. Although both Th1 and Th2 cells are present in the primary response, only Th1 cells up-regulate the IL- 13Rα1 chain. Consequently IL-13Rα1 can associate with IL-4Rα to form a heteroreceptor through which IL-4 from Th2 cells can signal and cause the apoptosis of Th1 cells upon secondary re-challenge with antigen. Formation of this IL-13Rα1/IL-4Rα heteroreceptor is influenced by two factors: the neonatal environment and intrinsic T cell factors.
URI: http://hdl.handle.net/10355/9205

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