Shared more. Cited more. Safe forever.
    • advanced search
    • submit works
    • about
    • help
    • contact us
    • login
    View Item 
    •   MOspace Home
    • University of Missouri-Columbia
    • Office of Undergraduate Research (MU)
    • Undergraduate Research and Creative Achievements Forum (MU)
    • 2006 Summer Undergraduate Research and Creative Achievements Forum (MU)
    • View Item
    •   MOspace Home
    • University of Missouri-Columbia
    • Office of Undergraduate Research (MU)
    • Undergraduate Research and Creative Achievements Forum (MU)
    • 2006 Summer Undergraduate Research and Creative Achievements Forum (MU)
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.
    advanced searchsubmit worksabouthelpcontact us

    Browse

    All of MOspaceCommunities & CollectionsDate IssuedAuthor/ContributorTitleIdentifierThesis DepartmentThesis AdvisorThesis SemesterThis CollectionDate IssuedAuthor/ContributorTitleIdentifierThesis DepartmentThesis AdvisorThesis Semester

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular AuthorsStatistics by Referrer

    Comparison of tumor imaging using antibody pretargeting and conventional methods [abstract]

    Williams, Imani
    Jia, Fang
    View/Open
    [PDF] Comparison of tumor imaging using antibody pretargeting.pdf (12.45Kb)
    Date
    2006
    Contributor
    University of Missouri-Columbia. Office of Undergraduate Research
    Format
    Abstract
    Metadata
    [+] Show full item record
    Abstract
    One of the newer methods for imaging and treating cancer is pretargeting. Pretargeting is a relatively simple concept to understand. First, a non-radioactive antibody conjugated to streptavidin is injected into the blood stream. The antibody is given time to reach the tumor and then it is cleared from the blood. Next, radioactive small molecules, like biotin, are administered and after a given amount of time, bound to the streptavidin-antibody at tumor site and cleared from the blood. Finally, the subject goes for imaging to get an accurate look at the size and growth of the tumor for possible treatment. One traditional form of imaging/treatment is radioimmunotherapy (RIT). Although antibodies are good at targeting tumor cells, with this approach, they were extremely toxic to the patient. Other limitations of RIT are high uptake into the blood, slow blood clearance, and slow and uneven penetration into tumors. Pretargeting is a good alternative because there is immediate uptake of radioactive material into the tumor and high tumor-to-normal tissue ratios.
     
    One of the newer methods for imaging and treating cancer is pretargeting. Pretargeting is a relatively simple concept to understand. First, a non-radioactive antibody conjugated to streptavidin is injected into the blood stream. The antibody is given time to reach the tumor and then it is cleared from the blood. Next, radioactive small molecules, like biotin, are administered and after a given amount of time, bound to the streptavidin-antibody at tumor site and cleared from the blood. Finally, the subject goes for imaging to get an accurate look at the size and growth of the tumor for possible treatment. One traditional form of imaging/treatment is radioimmunotherapy (RIT). Although antibodies are good at targeting tumor cells, with this approach, they were extremely toxic to the patient.  Other limitations of RIT are high uptake into the blood, slow blood clearance, and slow and uneven penetration into tumors. Pretargeting is a good alternative because there is immediate uptake of radioactive material into the tumor and high tumor-to-normal tissue ratios.
     
    URI
    http://hdl.handle.net/10355/922
    Collections
    • 2006 Summer Undergraduate Research and Creative Achievements Forum (MU)

    Send Feedback
    hosted by University of Missouri Library Systems
     

     


    Send Feedback
    hosted by University of Missouri Library Systems