Evaluation of [99MTc]glucarate as a breast cancer imaging agent: bench to bedside [abstract]
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The use of [99mTc]glucarate has been reported as an infarct-avid agent with the potential for very early detection of myocardial infarction. [99mTc]glucarate has also been postulated as an agent for non-invasive detection of tumors. The aim of the study was to develop a glucarate kit and evaluate [99mTc]glucarate as a potential cancer imaging agent in female SCID mice bearing human MDA-MB-435 breast tumors and in preliminary patient studies.