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    Gene transfer technology : a tool for studying gene function and role in corneal pathogenesis [abstract]

    Killion, Elizabeth A.
    Sharma, Ajay
    Tovey, Jonathan
    Tandon, Ashish
    Gupta, Rangan, 1978-
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    [PDF] GeneTransferTechnology.pdf (224.0Kb)
    Date
    2010
    Contributor
    University of Missouri--Columbia. School of Medicine
    Format
    Abstract
    Metadata
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    Abstract
    Transforming growth factor β (TGFb) is associated with many corneal pathologies, diseases and dystrophies. The function of TGFb in adult corneas cannot be studied using conventional transgenic approach because TGFb1 and TGFb2 deficient transgenic animals suffer multiple inflammatory diseases, severe developmental defects, and death by 3-4 weeks of age. This study tested the hypothesis that selective tissue-targeted gene transfer approaches will permit examination of TGFb gene function in the adult cornea without altering TGFb expression in vital organs.
    URI
    http://hdl.handle.net/10355/9243
    Rights
    OpenAccess.
    This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License.
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