dc.contributor.advisor | Mohan, Rajiv R. | eng |
dc.contributor.author | Killion, Elizabeth A. | eng |
dc.contributor.author | Sharma, Ajay | eng |
dc.contributor.author | Tovey, Jonathan | eng |
dc.contributor.author | Tandon, Ashish | eng |
dc.contributor.author | Gupta, Rangan, 1978- | eng |
dc.contributor.corporatename | University of Missouri--Columbia. School of Medicine | eng |
dc.contributor.meetingname | Health Sciences Research Day (2010 : University of Missouri) | eng |
dc.date.issued | 2010 | eng |
dc.description.abstract | Transforming growth factor β (TGFb) is associated with many corneal pathologies, diseases and dystrophies. The function of TGFb in adult corneas cannot be studied using conventional transgenic approach because TGFb1 and TGFb2 deficient transgenic animals suffer multiple inflammatory diseases, severe developmental defects, and death by 3-4 weeks of age. This study tested the hypothesis that selective tissue-targeted gene transfer approaches will permit examination of TGFb gene function in the adult cornea without altering TGFb expression in vital organs. | eng |
dc.format.extent | 1 page | eng |
dc.identifier.uri | http://hdl.handle.net/10355/9243 | |
dc.language | English | eng |
dc.relation.ispartofcommunity | University of Missouri--Columbia. Health Sciences Research Day | eng |
dc.rights | OpenAccess. | eng |
dc.rights.license | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License. | eng |
dc.subject | corneal abnormalities | eng |
dc.subject | therapeutic targets | eng |
dc.subject.FAST | Genetic transformation | eng |
dc.subject.FAST | Cornea -- Diseases | eng |
dc.title | Gene transfer technology : a tool for studying gene function and role in corneal pathogenesis [abstract] | eng |
dc.type | Abstract | eng |