Green tea epigallocatechin-3-gallate (EGCG) inhibits cytokine-induced nitric oxide and secretory phospholipase A2-IIA in glial cells [abstract]
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Glial cells, including astrocytes and microglial cells, are activated in response to injury and neurodegenerative diseases. In culture studies, astrocytes and microglial cells are capable of responding to proinflammatory cytokines and lipopolysacharides (LPS), which cause the induction of inflammatory factors, including inducible nitric oxide synthase (iNOS) and secretory phospholipase A2 (sPLA2). In our recent studies, we provided evidence for specific conditions for induction of iNOS and sPLA2-IIA in immortalized glial cell lines, including the murine BV-2 microglial cells, rat HAPI microglial cells, and rat DITNC astrocytes.