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dc.contributor.advisorReinero, Carol R.eng
dc.contributor.authorSharp, Claireeng
dc.date.issued2010eng
dc.date.submitted2010 Summereng
dc.descriptionThe entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file.eng
dc.descriptionTitle from PDF of title page (University of Missouri--Columbia, viewed on November 9, 2010).eng
dc.descriptionIncludes bibliographical referenceseng
dc.descriptionThesis advisor: Carol Reinero.eng
dc.description"August 2010"eng
dc.descriptionM.S. University of Missouri-Columbia 2010.eng
dc.descriptionDissertations, Academic -- University of Missouri--Columbia -- Veterinary biomedical sciences.eng
dc.description.abstractIntroduction: Directed, effective therapies for feline sepsis are needed to reduce the high morbidity and mortality associated with this disease. Materials and Methods: We investigated the anti-endotoxin effects of PMB in a blinded, placebo controlled fashion, both ex vivo in a feline whole blood culture system and in vivo, using a low-dose endotoxin infusion in cats (2ug/kg/hr IV x 4 hours). Serial measures of systemic inflammation, and hemodynamic stability, were compared between groups. Results: Ex vivo, PMB significantly decreased LPS-induced TNF production from whole blood. In vivo, endotoxin infusion resulted in the development of fever, hypotension, leucopenia and increased TNF activity. Polymyxin B (1mg/kg over 30 minutes) treatment decreased peak plasma TNF activity (p<0.001) and increased white blood cell count (p=0.019), with no adverse effects. Conclusions: Polymyxin B administration resulted in decreased peak plasma TNF activity and increased white blood cell count in this feline model of endotoxemia, with no adverse effects. Given the apparent safety and anti-endotoxin effects of PMB in this endotoxemia model, a carefully designed, randomized, blinded, placebo controlled clinical trial evaluating the use of PMB in naturally occurring Gram negative feline sepsis should be considered.eng
dc.format.extentxi, 55 pageseng
dc.identifier.merlinb80699352eng
dc.identifier.oclc680039178eng
dc.identifier.otherSharpC-082410-T24eng
dc.identifier.urihttp://hdl.handle.net/10355/9298eng
dc.languageEnglisheng
dc.publisherUniversity of Missouri--Columbiaeng
dc.relation.ispartof2010 Freely available theses (MU)eng
dc.relation.ispartofcommunityUniversity of Missouri-Columbia. Graduate School. Theses and Dissertations. Theses. 2010 Theseseng
dc.subject.lcshEndotoxemia -- Treatmenteng
dc.subject.lcshCats -- Diseases -- Treatmenteng
dc.subject.lcshPolymyxin -- Therapeutic useeng
dc.titleThe antiendotoxin effects of polymyxin B in a feline model of endotoxemiaeng
dc.typeThesiseng
thesis.degree.disciplineVeterinary biomedical sciences (MU)eng
thesis.degree.grantorUniversity of Missouri--Columbiaeng
thesis.degree.levelMasterseng
thesis.degree.nameM.S.eng


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