Hydrogen sulfide (H2S) augments synaptic neurotransmission in the nucleus of the solitary tract (NTS) [abstract]
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Hydrogen sulfide (H2S) is a gasotransmitter generated through the metabolism of cysteine to serine. In the central nervous system, H2S is produced primarily by the enzyme cystanthionine [beta]-synthase (CBS). The brainstem nTS serves as the principal site for sensory afferent integration for cardiorespiratory regulation. We sought to determine the role of H2S, and its generation by CBS, in nTS excitability in normoxia and following chronic intermittent hypoxia (CIH), a rodent model of sleep apnea.
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