Intracranial and whole brain volumes in infants with sagittal craniosynostosis
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Single-suture craniosynostosis occurs in approximately1 in 2000 live births and has been associated with brain dysmorphology. It has been suggested that premature fusion of cranial sutures restricts and alters brain growth by limiting the space within the cranial vault, leading to the hypothesis that cognitive deficits result from reduced intracranial volume. Here we test the hypothesis that intracranial volumes and whole brain volumes in infants diagnosed with isolated sagittal synostosis differ from those of unaffected infants.