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    Intrinsic high aerobic capacity protects against lipid induced hepatic insulin resistance [abstract]

    Morris, E. Matthew
    Uptergrove, Grace M.E.
    Koch, Lauren
    Britton, Steve L.
    Ibdah, Jamal A.
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    [PDF] IntrinsicHighAerobicCapacity.pdf (223.5Kb)
    Date
    2010
    Contributor
    University of Missouri--Columbia. School of Medicine
    Format
    Abstract
    Metadata
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    Abstract
    Hepatic steatosis is commonly linked to hepatic insulin resistance. However, recent studies have found that increased hepatic triacylglycerol (TAG) accumulation is not always associated with impaired hepatic insulin signaling, leading to a hypothesis that partitioning of lipids into TAG in the liver matched with high rates of fatty acid oxidation (FAO) under high lipid exposure conditions may protect against hepatic insulin resistance. We examined this hypothesis in the livers of high and low capacity running (HCR/LCR) rats which were created by artificial selection based on differences in intrinsic aerobic capacity.
    URI
    http://hdl.handle.net/10355/9337
    Rights
    OpenAccess.
    This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License.
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