Lectin affinity binding of pseudononas aeruginosa with polyacrylamide neoglycoconjugates [abstract]

Abstract

The main clinical feature of cystic fibrosis (CF) is a chronic progressive lung disease caused mainly by Pseudomonas aeruginosa (PA) infection. The mechanism of bacterial invasion is not very clear. It's been shown that PA recognizing specific saccharides through lectins on the airway surface could be the very first step during invasion and infection. This project aims to conduct a comprehensive analysis of saccharides that could bind to different PA isolates from CF patients.