MicroRNA mir-146a expression in oral cancer tissues [abstract]

Abstract

Recent advances in basic research have shown that the expression and function of microRNAs impact on gene expression regulation networks extensively. Ever increasing new knowledge from microRNA studies should be translated into medical practice if possible. Formalin-fixed paraffin-embedded (FFPE) human cancer tissues are a huge resource for delineating the role and potential application of microRNAs in cancer pathology. However, detecting microRNA in such cancer tissues with in situ hybridization is a challenge. The goal of this study was to demonstrate the feasibility of such approach in cancer research and practice.