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    Nebivolol, a beta adrenergic receptor antagonist blocks angiotensin II-mediated signaling in heart [abstract]

    Gul, Rukhsana
    DeMarco, Vincent G.
    Arnold, Shannon
    Whaley-Connell, Adam T.
    Sowers, James R. (James Russell), 1942-
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    [PDF] NebivololBetaAdrenergic.pdf (223.9Kb)
    Date
    2010
    Contributor
    University of Missouri--Columbia. School of Medicine
    Format
    Abstract
    Metadata
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    Abstract
    We recently showed that Nebivolol, a [beta]-adrenergic receptor (AR) antagonist attenuates myocardial oxidative stress and promotes insulin metabolic signaling in 9 week old Zucker obese (ZO) insulin resistant rats. Here, we demonstrate that Nebivolol suppresses angiotensin II type I receptor (AT1R)-mediated signaling in ZO hearts as well as in HL-1 cardiomyocytes.
    URI
    http://hdl.handle.net/10355/9368
    Rights
    OpenAccess.
    This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License.
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