Nebivolol, a beta adrenergic receptor antagonist blocks angiotensin II-mediated signaling in heart [abstract]

Gul, Rukhsana
DeMarco, Vincent G.
Arnold, Shannon
Whaley-Connell, Adam T.
Sowers, James R. (James Russell), 1942-
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Date
2010-11
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Abstract
We recently showed that Nebivolol, a β-adrenergic receptor (AR) antagonist attenuates myocardial oxidative stress and promotes insulin metabolic signaling in 9 week old Zucker obese (ZO) insulin resistant rats. Here, we demonstrate that Nebivolol suppresses angiotensin II type I receptor (AT1R)-mediated signaling in ZO hearts as well as in HL-1 cardiomyocytes.
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http://hdl.handle.net/10355/9368
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