Nicotine reduces adenosine release in the lateral hypothalamus: a possible mechanism of its addiction [abstract]
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Nicotine (tobacco) addiction is a serious health issue and a leading cause of death. However, the mechanism of nicotine addiction is not fully understood. Previous reports suggest that nicotine induced activation of orexin neurons in the lateral hypothalamus (LH) region of the brain may play an important role in nicotine addiction. Adenosine is implicated to inhibit orexin neurons. Does nicotine reduce adenosine release in the LH and thereby causing disinhibition/ activation of orexin neurons?