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    Overexpression of the RNA-binding protein HuR impairs tumor growth in triple negative breast cancer associated with deficient angiogenesis [abstract]

    Gubin, Matthew M.
    Calaluce, Robert
    Davis, J. Wade
    Magee, Joseph D.
    Strouse, Connie S.
    Shaw, Daniel P.
    Hoffman, Timothy Joseph, 1958-
    Rold, Tammy L.
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    [PDF] OverexpressionRNABindingProtein.pdf (223.8Kb)
    Date
    2010
    Contributor
    University of Missouri--Columbia. School of Medicine
    Format
    Abstract
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    Abstract
    Breast cancer is the second most common cancer in women and causes the death of 519,000 people worldwide. Many cancer genes are posttranscriptionally regulated by RNA-binding proteins (RBPs) and microRNAs. The RBP HuR binds to the AU-rich (ARE) regions of labile mRNAs, such as proto-oncogenes, stabilizing their mRNA and facilitating their translation into protein. HuR has been described to control genes in multiple areas of the acquired capabilities model of cancer and has been hypothesized to be a tumor maintenance gene, allowing for cancers to proliferate once they are established. We investigated the role of HuR in aggressive and difficult to treat triple-negative breast cancer.
    URI
    http://hdl.handle.net/10355/9380
    Rights
    OpenAccess.
    This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License.
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