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dc.contributor.advisorAtasoy, Ulus X.eng
dc.contributor.authorGubin, Matthew M.eng
dc.contributor.authorCalaluce, Roberteng
dc.contributor.authorDavis, J. Wadeeng
dc.contributor.authorMagee, Joseph D.eng
dc.contributor.authorStrouse, Connie S.eng
dc.contributor.authorShaw, Daniel P.eng
dc.contributor.authorHoffman, Timothy Joseph, 1958-eng
dc.contributor.authorRold, Tammy L.eng
dc.contributor.corporatenameUniversity of Missouri--Columbia. School of Medicineeng
dc.contributor.meetingnameHealth Sciences Research Day (2010 : University of Missouri)eng
dc.date.issued2010eng
dc.description.abstractBreast cancer is the second most common cancer in women and causes the death of 519,000 people worldwide. Many cancer genes are posttranscriptionally regulated by RNA-binding proteins (RBPs) and microRNAs. The RBP HuR binds to the AU-rich (ARE) regions of labile mRNAs, such as proto-oncogenes, stabilizing their mRNA and facilitating their translation into protein. HuR has been described to control genes in multiple areas of the acquired capabilities model of cancer and has been hypothesized to be a tumor maintenance gene, allowing for cancers to proliferate once they are established. We investigated the role of HuR in aggressive and difficult to treat triple-negative breast cancer.eng
dc.format.extent1 pageeng
dc.identifier.urihttp://hdl.handle.net/10355/9380
dc.languageEnglisheng
dc.relation.ispartofcommunityUniversity of Missouri--Columbia. Health Sciences Research Dayeng
dc.rightsOpenAccess.eng
dc.rights.licenseThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License.eng
dc.subjecttumor growtheng
dc.subjectmonotherapieseng
dc.subject.FASTBreast -- Cancereng
dc.subject.FASTRNA-protein interactionseng
dc.subject.FASTNeovascularizationeng
dc.titleOverexpression of the RNA-binding protein HuR impairs tumor growth in triple negative breast cancer associated with deficient angiogenesis [abstract]eng
dc.typeAbstracteng


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