The role of DNA methylation on gene expression in actue lymphoblastic leukemia
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Epigenetic modification of the genome has more influence on gene expression than DNA sequence alone. DNA hypermethylation and deacetylation of histone complexes has been shown to down regulate expression of associated genes. These epigenetic modifications may play an important role in the pathogenesis of cancer. Demethylation agents and histone deacytlase inhibitors used to restore gene activity to previous levels could lead to development of novel anti-cancer drugs.