SAHA: FDA approved histone deacetylase inhibitor demonstrates exceptionally high inhibition of corneal haze following PRK surgery in rabbit model [abstract]

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SAHA: FDA approved histone deacetylase inhibitor demonstrates exceptionally high inhibition of corneal haze following PRK surgery in rabbit model [abstract]

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Title: SAHA: FDA approved histone deacetylase inhibitor demonstrates exceptionally high inhibition of corneal haze following PRK surgery in rabbit model [abstract]
Author: Waggoner, Michael; Tandon, Ashish; Tovey, Jonathan; Sharma, Ajay; Lopez, Vanessa; Cowden, John W.; Rieger, Frank G., III; Hamm, Chuck W.
Keywords: eye injury
occluded vision
Date: 2010-11-11
Abstract: TGFβ induces the transformation of corneal keratocytes into fibroblasts and myofibroblasts resulting in the formation of corneal haze (scar) following injury. We investigated whether epigenetic modifications can prevent development of corneal haze in vivo using a rabbit model.
URI: http://hdl.handle.net/10355/9407

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