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    Sleep deprivation causes epigenetic changes in the basal forebrain [abstract]

    deRoode, David
    Sharma, Rishi
    Lodhi, Shafi
    Forman, Suzanne
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    [PDF] SleepDisorderCausesEpigenetic.pdf (223.7Kb)
    Date
    2010
    Contributor
    University of Missouri--Columbia. School of Medicine
    Format
    Abstract
    Metadata
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    Abstract
    Today's work pressure has lead people to curtail their sleep. However, all of the consequences of sleep deprivation are not clear. Histone acetylation is a key epigenetic mechanism responsible for controlling gene expression. Increased histone acetylation increases gene expression; reduced histone acetylation results in reduced gene expression. We hypothesized that as compared to spontaneous wakefulness, sleep deprivation may produce a significant increase in histone acetylation in the basal forebrain (BF) region. We chose the BF region because it is a critical brain region responsible for regulating various brain functions including sleep, vigilance, attention, learning and memory.
    URI
    http://hdl.handle.net/10355/9413
    Rights
    OpenAccess.
    This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License.
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