17-Alpha hydroxyprogesterone for reducing preterm labor
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Supplementation with intramuscular 17-alpha hydroxyprogesterone caproate (17P) significantly reduces the incidence of preterm delivery for women at increased risk of preterm birth. All women with a singleton pregnancy and a history of prior preterm birth should be offered weekly injections. Additional studies are needed to investigate use in women with a short cervix, multiple gestations, and in arrest of preterm labor. Complete maternal and fetal safety profiles, as well as ideal dose, route of administration, and duration of treatment, are also evolving.
Evidence Based Practice 13(10): 11.