Is statin therapy safe and effective for hyperlipidemia in patients with baseline elevated liver function tests or chronic liver disease?
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Statins are safe and effective for improving lipid profiles in patients with chronic, stable liver disease, such as nonalcoholic fatty liver disease (NAFLD), steatohepatitis, and compensated cirrhosis with baseline transaminase elevation. In these situations, statins are not associated with any significant increase in transaminases or acute liver injury over placebo. (SOR: B, based on subgroup analysis in a systematic review, an RCT, and cohort studies.)
Evidence Based Practice 13(10): 13.