Risks and benefits of creatine supplementation
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Creatine supplementation increases muscle power output in as little as 1 week. (SOR: A, based on consistent RCTs.) Even patients with hereditary muscular dystrophies experience increased muscle strength. (SOR: A, based on a systematic review.) Creatine appears to elevate serum creatine kinase activity, but the clinical significance of this effect is unclear. (SOR: C, based on bench research with limited numbers of patients.) Dose-dependent diarrhea is the most notable side effect. (SOR: B, based on a single RCT.)
Evidence Based Practice 13(10): 19.