Is clopidogrel plus aspirin superior to aspirin alone for primary prevention of cardiovascular outcomes among patients with multiple risk factors?
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The addition of clopidogrel to aspirin therapy is not superior to aspirin therapy alone for primary prevention. In addition, medical therapy with a combination of clopidogrel and aspirin increases the risk of moderate to severe bleeding compared with aspirin alone. (SOR: B, based on an RCT.)
Evidence Based Practice 13(11): 12.