What are the adverse effects of aggressive glucose control in type 2 diabetes?
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Although maintaining a 10-year median A1c of 7.0% significantly decreases the rate of overall mortality and myocardial infarction (MI) over long-term follow-up (compared with a median A1c of 7.9%), more aggressive glucose control with a median achieved A1c of 6.4% has no known benefit and may increase mortality. (SOR: B, based on conflicting RCTs.)
Evidence Based Practice 13(12): 08-09.