RSS 1.0Pathology and Anatomical Sciences electronic theses and dissertations (MU)
The items in this collection are the theses and dissertations written by students of the Department of Pathology and Anatomical Sciences. Some items may be viewed only by members of the University of Missouri System and/or University of Missouri-Columbia. Click on one of the browse buttons above for a complete listing of the works.
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Recent Submissions
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Avian β-defensins as antimicrobial and immunomodulatory agents
(University of Missouri--Columbia, 2018)The increasing prevalence of antibiotic-resistance and lack of effective antibiotics pose a serious threat to animal health and public health. Host antimicrobial peptides (AMPs) show broad-spectrum antimicrobial activity ... -
Mechanisms of Alphavirus Midgut dissemination in the Mosquito, Aedes aegypti
(University of Missouri--Columbia, 2018)The research work of this thesis has focused on the midgut escape barrier and the dissemination mechanism of alphaviruses in Ae. aegypti. Primarily, we identified and characterized Ae. aegypti MMPs that are seemingly ... -
Advancements in the understanding of staphylococcal mastitis through the use of molecular tools
(University of Missouri--Columbia, 2017)The objectives of this work were: 1) to complete a whole genome sequence of a Staphylococcus chromogenes isolate that is known to persist in the mammary gland of a cow, 2) to define a genetic target that could easily and ... -
Bivalent peptide-based radioconjugates for prostate cancer imaging and potential therapy
(University of Missouri--Columbia, 2017)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Introduction: Despite decades of research, prostate cancer remains an important disease, with 1 out of 7 men diagnosed within his lifetime. In 2017, ... -
Dimorphism and integration in the pelves of anthropoid primates
(University of Missouri--Columbia, 2016)The link between obstetric demand (natural selection for birth) and pelvic morphology in anthropoids has remained ambiguous for the past century. Though it is assumed that the dramatic sexual dimorphism seen in modern human ... -
RNA-sequencing analysis in B-cell acute lymphoblastic leukemia reveals aberrant gene expression and splicing alterations
(University of Missouri--Columbia, 2017)Background: B-cell acute lymphoblastic leukemia (B-ALL) is a neoplasm of immature lymphoid progenitors and is the leading cause of cancer-related death in children. The majority of B-ALL cases are characterized by recurring ... -
Computational modeling, ontogeny, and biomechanics of cranial forces in Alligator mississippiensis
(University of Missouri--Columbia, 2015)3D computational modeling offers researchers tools to investigate forces in the skull during feeding and other behaviors. The American alligator and other crocodylians generate the highest bite forces among vertebrates, ... -
Archosaur hip joint anatomy and its significance in body size and locomotor evolution
(University of Missouri--Columbia, 2015)Archosaurs (crocodylians, birds and their extinct relatives) underwent numerous evolutionary transitions in limb morphology and body size, reflecting a diverse suite of postural and behavioral adaptations. Among archosaurs, ... -
Grasping pressures and phalangeal curvature in primates: an experimental in vivo approach
(University of Missouri--Columbia, 2015)Phalangeal curvature is often used to infer arboreal locomotion in fossil primate species. This is based off an hypothesis of plasticity linked to a loading model that suggests that, when flexed during grasping, a curved ... -
Global DNA methylation and gene expression analysis in pre-B cell acute lymphoblastic leukemia
(University of Missouri--Columbia, 2015)Acute lymphoblastic leukemia (ALL) is a hematological cancer associated with precursor B-cells and is the most common cancer diagnosed in children under the age of 15. Our complete understanding of all mechanisms responsible ... -
Comprehensive profiling of micro RNA in human papillomavirus-associated squamous cell carcinoma of the head and neck
(University of Missouri--Columbia, 2014) -
Patients with venous thromboembolism have higher prevalence of obstructive sleep apnea than the general population
(University of Missouri--Columbia, 2010)Study Objectives: Obstructive sleep apnea (OSA) has been linked to a large number of cardiovascular diseases. However, the link between OSA and venous thromboembolic events (VTE) remains unclear. We sought to study the ... -
3D analysis of hip joint mobility and the evolution of locomotor abilities in miocene hominoids
(University of Missouri--Columbia, 2013)The emergence of extant ape-like locomotor behaviors has become a defining issue in reconstructing ape evolution. Suspensory positional behaviors, such as antipronograde bridging, climbing, clambering and transfer, distinguish ... -
Aberrant DNA methylationof RUN domain containing 3B in lymphoid malignancies
(University of Missouri--Columbia, 2013)Heritable changes to DNA conformation can have significant impacts on gene expression without altering the DNA sequence. The RUN domain containing 3B gene (RUNDC3B) has been shown to be differentially expressed in cancer ... -
Development of post-traumatic osteoarthritis models to evaluate the effects of impact injury on joint health for clinical disease treatment and prevention
(University of Missouri--Columbia, 2013)Osteoarthritis is one of the most common, debilitating, musculoskeletal diseases in the world. Currently, there is no cure. It is well-known that a traumatic, joint injury increases the risk of developing post-traumatic ... -
Of mice and men: can MMP-9 be a biomarker and a potential target for treatment after traumatic brain injury?
(University of Missouri--Columbia, 2013)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Traumatic brain injury (TBI) is a highly prevalent cause of death and disability in the US and has become a significant burden to our present healthcare ... -
Administration of apocynin in drinking water ameliorates transient cerebral ischemia-induced brain damage and behavioral deficits in mice
(University of Missouri--Columbia, 2012)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Acute ischemic stroke is the third leading cause of death in developed countries and the most frequent cause of permanent disability in adults worldwide. ... -
Mechanism-based inhibition of matrix metalloproteinase-9 provides neuroprotection in a mouse model of traumatic brain injury
(University of Missouri--Columbia, 2012)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Traumatic brain injury (TBI) is a leading cause of death and disability in the U.S. Following an initial mechanical impact, TBI progresses to a secondary ... -
Deregulation of the notch signaling pathway N B-cell chronic lymphocytic leukemia
(University of Missouri--Columbia, 2011)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] B-cell Chronic Lymphocytic Leukemia (B-CLL) is the most common hematological malignancy in United States[1], characterized by CD5+ B-lymphocytes in ... -
Kallikrein-5 promotes cleavage of desmoglein-1 and loss of cell-cell cohesion in oral squamous cell carcinoma
(University of Missouri--Columbia, 2010)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Oral squamous cell carcinoma (OSCC) is one of the top 10 causes of cancer deaths worldwide, with a 50% 5-year survival rate, necessitating the discovery ...