RSS 1.0Pathology and Anatomical Sciences electronic theses and dissertations (MU)
The items in this collection are the theses and dissertations written by students of the Department of Pathology and Anatomical Sciences. Some items may be viewed only by members of the University of Missouri System and/or University of Missouri-Columbia. Click on one of the browse buttons above for a complete listing of the works.
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Recent Submissions
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Computational modeling, ontogeny, and biomechanics of cranial forces in Alligator mississippiensis
(University of Missouri--Columbia, 2015)3D computational modeling offers researchers tools to investigate forces in the skull during feeding and other behaviors. The American alligator and other crocodylians generate the highest bite forces among vertebrates, ... -
Archosaur hip joint anatomy and its significance in body size and locomotor evolution
(University of Missouri--Columbia, 2015)Archosaurs (crocodylians, birds and their extinct relatives) underwent numerous evolutionary transitions in limb morphology and body size, reflecting a diverse suite of postural and behavioral adaptations. Among archosaurs, ... -
Grasping pressures and phalangeal curvature in primates: an experimental in vivo approach
(University of Missouri--Columbia, 2015)Phalangeal curvature is often used to infer arboreal locomotion in fossil primate species. This is based off an hypothesis of plasticity linked to a loading model that suggests that, when flexed during grasping, a curved ... -
Global DNA methylation and gene expression analysis in pre-B cell acute lymphoblastic leukemia
(University of Missouri--Columbia, 2015)Acute lymphoblastic leukemia (ALL) is a hematological cancer associated with precursor B-cells and is the most common cancer diagnosed in children under the age of 15. Our complete understanding of all mechanisms responsible ... -
Comprehensive profiling of micro RNA in human papillomavirus-associated squamous cell carcinoma of the head and neck
(University of Missouri--Columbia, 2014) -
Patients with venous thromboembolism have higher prevalence of obstructive sleep apnea than the general population
(University of Missouri--Columbia, 2010)Study Objectives: Obstructive sleep apnea (OSA) has been linked to a large number of cardiovascular diseases. However, the link between OSA and venous thromboembolic events (VTE) remains unclear. We sought to study the ... -
3D analysis of hip joint mobility and the evolution of locomotor abilities in miocene hominoids
(University of Missouri--Columbia, 2013)The emergence of extant ape-like locomotor behaviors has become a defining issue in reconstructing ape evolution. Suspensory positional behaviors, such as antipronograde bridging, climbing, clambering and transfer, distinguish ... -
Aberrant DNA methylationof RUN domain containing 3B in lymphoid malignancies
(University of Missouri--Columbia, 2013)Heritable changes to DNA conformation can have significant impacts on gene expression without altering the DNA sequence. The RUN domain containing 3B gene (RUNDC3B) has been shown to be differentially expressed in cancer ... -
Development of post-traumatic osteoarthritis models to evaluate the effects of impact injury on joint health for clinical disease treatment and prevention
(University of Missouri--Columbia, 2013)Osteoarthritis is one of the most common, debilitating, musculoskeletal diseases in the world. Currently, there is no cure. It is well-known that a traumatic, joint injury increases the risk of developing post-traumatic ... -
Of mice and men: can MMP-9 be a biomarker and a potential target for treatment after traumatic brain injury?
(University of Missouri--Columbia, 2013)Traumatic brain injury (TBI) is a highly prevalent cause of death and disability in the US and has become a significant burden to our present healthcare system. Currently there are few biomarkers and clinical diagnostic ... -
The presence of Nissl's bodies and neurofibrillae in the freshly fixed spinal nerve cell
(University of Missouri, 1912)Since the discovery of Nissl's bodies and neurofibrillae much work has been done on these structures. Nevertheless, some have even questioned their presence in the living nerve cell and have considered them as artifacts. ... -
The morphological changes of the purkinje cells of the cerebellum in heat exhaustion in correlation with the changes of normal functional activity
(University of Missouri, 1912)The condition of heat exhaustion, insolation or heat stroke has, in the past ten years, been thoroughly studied from a clinical point of view by observations of the signs and symptoms of the recovery cases, together with ... -
Age as a factor in animal breeding
(University of Missouri, 1918)The experiment furnishing the basis for this discussion was begun in 1909 by Director F.B. Mumford and has since been continued under his general direction. Swine were used in the experiment since they probably lend ... -
Thoracic index in the Negro
(University of Missouri, 1905)The following investigations were undertaken in order to determine the thoracic index, (i. e. the ratio of the antero-posterior to the transverse diameter) according to age and sex in the Negro, by means of a series of ... -
Administration of apocynin in drinking water ameliorates transient cerebral ischemia-induced brain damage and behavioral deficits in mice
(University of Missouri--Columbia, 2012)Acute ischemic stroke is the third leading cause of death in developed countries and the most frequent cause of permanent disability in adults worldwide. Despite advances in the understanding of the pathophysiology of ... -
Mechanism-based inhibition of matrix metalloproteinase-9 provides neuroprotection in a mouse model of traumatic brain injury
(University of Missouri--Columbia, 2012)Traumatic brain injury (TBI) is a leading cause of death and disability in the U.S. Following an initial mechanical impact, TBI progresses to a secondary injury phase characterized by events that exacerbate brain damage. ... -
The development of the administration of public health and safety, Kansas City, Missouri
(University of Missouri, 1907)As indicated by the title, this is a study of the development of administration in the field of Public Health and Safety in Kansas City. Mr. Fairlie in his Municipal Administration includes within this field Economic ... -
Deregulation of the notch signaling pathway N B-cell chronic lymphocytic leukemia
(University of Missouri--Columbia, 2011)B-cell Chronic Lymphocytic Leukemia (B-CLL) is the most common hematological malignancy in United States[1], characterized by CD5+ B-lymphocytes in peripheral blood. Deregulation of the Notch signaling pathway has been ... -
Kallikrein-5 promotes cleavage of desmoglein-1 and loss of cell-cell cohesion in oral squamous cell carcinoma
(University of Missouri--Columbia, 2010)Oral squamous cell carcinoma (OSCC) is one of the top 10 causes of cancer deaths worldwide, with a 50% 5-year survival rate, necessitating the discovery of novel biomarkers. Using cDNA microarray analyses, we identified ...