RSS 1.0Pathology and Anatomical Sciences electronic theses and dissertations (MU)
The items in this collection are the theses and dissertations written by students of the Department of Pathology and Anatomical Sciences. Some items may be viewed only by members of the University of Missouri System and/or University of Missouri-Columbia. Click on one of the browse buttons above for a complete listing of the works.
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Recent Submissions
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The use of massively parallel sequencing to study the virome, epigenome and genome of canine and feline cancers
(University of Missouri--Columbia, 2019)The remarkable advancements in sequencing technologies have allowed the entire mutational landscape of hundreds of different types of human cancers to be defined. This knowledge gives patients two new categories of treatment ... -
Comparative biomechanics of cranial kinesis in reptiles
(University of Missouri--Columbia, 2020)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] "The vertebrate skull is a composite organ made from structures that arise from different developmental, evolutionary and biomechanical phenomena. Of ... -
Biological responses of ligament and tendon graft-derived fibroblasts to clinical levels of cyclic strain
(University of Missouri--Columbia, 2020)Anterior Cruciate Ligament (ACL) is one of the major ligaments in the knee. ACL injury is the partial or complete tear of the ACL usually as a consequence of a traumatic sports related injury. ACL injury commonly affects ... -
Genetic and microbiota-mediated phenotype variability in the min mouse model of human colorectal cancer
(University of Missouri--Columbia, 2019)Complex diseases develop as a result of genetic predisposition and environmental factors that determine individual risk. Environmental factors such as geographical location, diet, and lifestyle choices shape the gut ... -
Defining recurrent laryngeal nerve injury in a mouse model for regenerative therapeutic investigations
(University of Missouri--Columbia, 2019)Injury of the recurrent laryngeal nerve (RLN), a branch of the vagus nerve, results in ipsilateral vocal fold (VF) paralysis that contributes to dysphagia, dysphonia, and dyspnea (i.e., swallow, vocal, and respiratory ... -
Reflux, aspiration and respiratory disease in dogs : clinical consideration and advances in aerodigestive diagnostics
(University of Missouri--Columbia, 2019)The aspiration of gastric contents into the respiratory tract has been associated with the development and progression of multiple respiratory diseases in humans. In veterinary medicine the term “aspiration” is considered ... -
Morphological and biomechanical predictions of cranial kinesis in reptile evolution
(University of Missouri--Columbia, 2019)Feeding is a complex behavior that all tetrapods engage in on a regular basis to procure energy and survive. The reptilian feeding apparatus includes many types of feeding behaviors including multiple methods of engaging ... -
Impacts of artificial light and melatonin signaling pathways on behavior and skeletal physiology in mice
(University of Missouri--Columbia, 2019)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] The natural cycles of light and darkness are a major feature of the environment for most species; thus, circadian physiology is rooted in the expectation ... -
Rat modeling of ovarian tissue cryopreservation and auto-grafting
(University of Missouri--Columbia, 2019)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] New advancements in cancer treatment methods are increasing the survival rate of cancer patients. Unfortunately, these life-saving treatments, such ... -
Plastic and evolved morphological responses of the hind limb skeleton to mechanical loading in mice
(University of Missouri--Columbia, 2018)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Skeletal morphology is determined by a combination of genetic background and phenotypic plasticity induced by mechanical loading. The changes in limb ... -
Epidemiology of non-aureus staphylococcal mastitis in dairy goats
(University of Missouri--Columbia, 2018)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] The hypothesis of this work was that molecular-based speciation and strain-typing methods would help differentiate staphylococcal species with greater ... -
Ultrastructural damages in the brain induced by low-intensity primary blast wave : a transmission electron microscopy study on mild traumatic brain injury
(University of Missouri--Columbia, 2018)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Explosive blast-induced mild traumatic brain injury (mTBI), a "signature wound" of recent military conflicts, commonly affects Service Members. While ... -
Avian [beta]-defensins as antimicrobial and immunomodulatory agents
(University of Missouri--Columbia, 2018)The increasing prevalence of antibiotic-resistance and lack of effective antibiotics pose a serious threat to animal health and public health. Host antimicrobial peptides (AMPs) show broad-spectrum antimicrobial activity ... -
Mechanisms of Alphavirus Midgut dissemination in the Mosquito, Aedes aegypti
(University of Missouri--Columbia, 2018)The research work of this thesis has focused on the midgut escape barrier and the dissemination mechanism of alphaviruses in Ae. aegypti. Primarily, we identified and characterized Ae. aegypti MMPs that are seemingly ... -
Advancements in the understanding of staphylococcal mastitis through the use of molecular tools
(University of Missouri--Columbia, 2017)The objectives of this work were: 1) to complete a whole genome sequence of a Staphylococcus chromogenes isolate that is known to persist in the mammary gland of a cow, 2) to define a genetic target that could easily and ... -
Bivalent peptide-based radioconjugates for prostate cancer imaging and potential therapy
(University of Missouri--Columbia, 2017)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Introduction: Despite decades of research, prostate cancer remains an important disease, with 1 out of 7 men diagnosed within his lifetime. In 2017, ... -
Dimorphism and integration in the pelves of anthropoid primates
(University of Missouri--Columbia, 2016)The link between obstetric demand (natural selection for birth) and pelvic morphology in anthropoids has remained ambiguous for the past century. Though it is assumed that the dramatic sexual dimorphism seen in modern human ... -
RNA-sequencing analysis in B-cell acute lymphoblastic leukemia reveals aberrant gene expression and splicing alterations
(University of Missouri--Columbia, 2017)Background: B-cell acute lymphoblastic leukemia (B-ALL) is a neoplasm of immature lymphoid progenitors and is the leading cause of cancer-related death in children. The majority of B-ALL cases are characterized by recurring ... -
Computational modeling, ontogeny, and biomechanics of cranial forces in Alligator mississippiensis
(University of Missouri--Columbia, 2015)3D computational modeling offers researchers tools to investigate forces in the skull during feeding and other behaviors. The American alligator and other crocodylians generate the highest bite forces among vertebrates, ... -
Archosaur hip joint anatomy and its significance in body size and locomotor evolution
(University of Missouri--Columbia, 2015)Archosaurs (crocodylians, birds and their extinct relatives) underwent numerous evolutionary transitions in limb morphology and body size, reflecting a diverse suite of postural and behavioral adaptations. Among archosaurs, ...