Recent Submissions

  • Should RAAS blockade therapy be continued in patients with advanced renal disease? 

    Pham, Kim; Beyer, Carli; Guthmann, Rick (Family Physicians Inquiries Network, 2023-04)
    Q: Should RAAS blockade therapy be continued in patients with advanced renal disease? Evidence-based answer: PROBABLY. Renin-angiotensinaldosterone system (RAAS) blockade therapy should be continued in most patients with ...
  • Is there benefit to adding ezetimibe to a statin for the secondary prevention of CVD? 

    Reddy, Vinay; Allison, James; Mounsey, Anne; Guthmann, Rick (Family Physicians Inquiries Network, 2023-06)
    Q: Is there benefit to adding ezetimibe to a statin for the secondary prevention of CVD? Evidence-based answer: YES. In patients with known cardiovascular disease (CVD), ezetimibe with a statin decreases major adverse ...
  • Should antenatal testing be performed in patients with a pre-pregnancy BMI ≥ 35? 

    Dresang, Lee; Vellardita, Lia; Guthmann, Rick (Family Physicians Inquiries Network, 2023-03)
    Q: Should antenatal testing be performed in patients with a pre-pregnancy BMI ≥ 35? Evidence-based answer:Possibly. Elevated BMI is associated with an increased risk for stillbirth (strength of recommendation [SOR], B; ...
  • Is low-dose naltrexone effective in chronic pain management? 

    Radi, Roxanne; Huang, Harriet; Rivera, Jason; Lyon, Corey; DeSanto, Kristen; Guthmann, Rick (Family Physicians Inquiries Network, 2023-09)
    Q: Is low-dose naltrexone effective in chronic pain management? Evidence-based answer: YES. Low-dose naltrexone is as effective as amitriptyline in the treatment of painful diabetic neuropathy and has a superior safety ...
  • Does use of continuous or flash glucose monitors decrease hypoglycemia episodes in T2D? 

    Wen, Frances K.; Bigelow, Simone; Crosby, Kimberly; Reeder, Raye; Hoberecht, Toni; Moreau, Emrys; Guthmann, Rick (Family Physicians Inquiries Network, 2023-07)
    Q: Does use of continuous or flash glucose monitors decrease hypoglycemia episodes in T2D? Evidence-based answer: NO. In adults with insulin-treated type 2 diabetes (T2D), continuous glucose monitoring (CGM) and flash ...
  • Does regular walking improve lipid levels in adults? 

    Hatchell, Kayla; Chin, Emily; Vukelic, Brian; Fortenberry, Katherine; Ose, Dominick; Taylor, Eliza; Goossen, Rachel; Guthmann, Rick (Family Physicians Inquiries Network, 2023-01)
    Q: Evidence-based answer: Minimally. Regular moderateintensity walking for a period of 4 or more weeks minimally decreased total cholesterol (TC) and low-density lipoprotein (LDL) levels by about 7 mg/dL in women with ...
  • Does physical exercise reduce dementia-associated agitation? 

    Jabbour, Katarzyna; Wilson, Lynn M.; Mathieu, Susan S.; Keister, Drew; Guthmann, Rick (Family Physicians Inquiries Network, 2023-01)
    Q: Evidence-based answer: not consistently. Physical exercise demonstrates inconsistent benefit for neuropsychiatric symptoms, including agitation, in patients with dementia (strength of recommendation: b, inconsistent ...
  • Does hormone replacement therapy prevent cognitive decline in postmenopausal women? 

    Gates, Madeline; Beagle, Melissa; Bull, Lauren; Radi, Roxanne; Lyon, Corey; DeSanto, Kristen; Guthmann, Rick (Family Physicians Inquiries Network, 2023-05)
    Q: Evidence-based answer: NO. Hormone replacement therapy (HRT) does not prevent cognitive decline in postmenopausal women—and in fact, it may slightly increase risk (strength of recommendation, A; systematic review, ...