[-] Show simple item record

dc.contributor.advisorSher, Kenneth J.eng
dc.contributor.authorPark, Aesooneng
dc.coverage.spatialUnited Stateseng
dc.date.issued2009eng
dc.date.submitted2009 Summereng
dc.descriptionTitle from PDF of title page (University of Missouri--Columbia, viewed on September 17, 2010).eng
dc.descriptionThe entire thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file; a non-technical public abstract appears in the public.pdf file.eng
dc.descriptionDissertation advisor: Dr. Kenneth J. Sher.eng
dc.descriptionVita.eng
dc.descriptionIncludes bibliographical references.eng
dc.descriptionPh. D. University of Missouri--Columbia 2009.eng
dc.descriptionDissertations, Academic -- University of Missouri--Columbia -- Psychology.eng
dc.description.abstractAlcohol problems at different developmental stages are associated with different genetic and environmental factors. Taking a developmentally sensitive approach, the current study characterized interaction effects between monoamine gene polymorphisms and developmental environments on alcohol problems during emerging and young adulthood. Prospective data of a cohort of 454 Caucasian individuals assessed at the mean ages of 18 to 34 were used. A longitudinal hierarchical factor model was used to model one persistent alcohol problem factor throughout emerging and young adulthood and two residual alcohol problem factors limited to emerging adulthood and to young adulthood. Then, interaction effects between each of the DRD4 VNTR, DAT1 VNTR, and 5-HTTLPR genes and three developmental environments were modeled to account for those alcohol problem factors. Persistence of those environments was modeled as an enduring effect of childhood adversity on the persistent alcohol problem factor and situational effects of college involvement and delayed adult role transition on the two developmentally limited alcohol problem factors. Carriers of the DRD4 long allele showed greater persistent alcohol problems as childhood adversity increased and greater alcohol problems limited to emerging adulthood as college involvement increased. Alcohol problems among non-carriers of the long allele, however, did not differ as a function of childhood adversity and college involvement. For the DAT1 VNTR and the 5-HTTLPR polymorphisms, no significant gene-environment interaction was found. Although preliminary, these findings highlight the importance of modeling both distal and proximal environments and their interplay with genetic susceptibility in alcohol problems at specific developmental stages.eng
dc.format.extentiv, 40 pageseng
dc.identifier.oclc696795982eng
dc.identifier.urihttps://hdl.handle.net/10355/9684
dc.identifier.urihttps://doi.org/10.32469/10355/9684eng
dc.languageEnglisheng
dc.publisherUniversity of Missouri--Columbiaeng
dc.relation.ispartof2009 Freely available dissertations (MU)eng
dc.relation.ispartofcommunityUniversity of Missouri-Columbia. Graduate School. Theses and Dissertations. Dissertations. 2009 Dissertationseng
dc.subject.lcshGenetic polymorphismseng
dc.subject.lcshGenotype-environment interactioneng
dc.subject.lcshNeurotransmitter receptorseng
dc.subject.lcshYoung adults -- Alcohol useeng
dc.subject.lcshAlcoholism -- Preventioneng
dc.titleGene-environment interaction in alcohol problems in emerging and young adulthood: the DRD4 VNTR, DAT1 VNTR, and 5-HTTLPR polymorphismseng
dc.typeThesiseng
thesis.degree.disciplinePsychology (MU)eng
thesis.degree.grantorUniversity of Missouri--Columbiaeng
thesis.degree.levelDoctoraleng
thesis.degree.namePh. D.eng


Files in this item

[PDF]
[PDF]
[PDF]

This item appears in the following Collection(s)

[-] Show simple item record