[-] Show simple item record

dc.contributor.advisorCook, James L. (James Lee), 1965-eng
dc.contributor.authorBreshears, Lee A. (Lee Andrew), 1974-eng
dc.date.issued2008eng
dc.date.submitted2008 Springeng
dc.descriptionThe entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file.eng
dc.descriptionTitle from PDF of title page (University of Missouri--Columbia, viewed on January 24, 2011).eng
dc.descriptionVita.eng
dc.descriptionThesis advisor: James L. Cook.eng
dc.descriptionPh. D. University of Missouri-Columbia 2008.eng
dc.description.abstractThe pathogenesis of cruciate ligament disease and how it may be linked to the initiation and progression of osteoarthritis were investigated using in vitro and in vivo models. Normal and diseased tissues were initially evaluated to identify genes that may be involved in this disease process. Structural, degradative and inflammatory genes were found to be expressed differentially in these tissues. Gene expression data corresponded well to protein expression when investigated. The role of mechanotransduction in ligament health was investigated. Strain amplitude and duration were found to affect these differentially expressed genes. The Pond-Nuki model was utilized to investigate and confirm the role of these genes in vivo. A novel method of matrix metalloproteinase detection was compared to traditional techniques and found to be superior to techniques currently utilized in the literature. Further investigation of these genes and molecules in cruciate ligament pathogenesis is warranted.eng
dc.description.bibrefIncludes bibliographical referenceseng
dc.format.extentix, 172 pageseng
dc.identifier.oclc698126601eng
dc.identifier.urihttps://hdl.handle.net/10355/9735
dc.identifier.urihttps://doi.org/10.32469/10355/9735eng
dc.languageEnglisheng
dc.publisherUniversity of Missouri--Columbiaeng
dc.relation.ispartofcommunityUniversity of Missouri--Columbia. Graduate School. Theses and Dissertationseng
dc.rightsOpenAccess.eng
dc.rights.licenseThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License.
dc.subject.lcshCruciate ligaments -- pathophysiologyeng
dc.subject.lcshOsteoarthritis -- pathogenesiseng
dc.subject.lcshCellular signal transductioneng
dc.subject.lcshGene expressioneng
dc.titleCruciate ligament pathogenesis and its role in the initiation and progression of osteoarthritiseng
dc.typeThesiseng
thesis.degree.disciplineVeterinary pathobiology area program (MU)eng
thesis.degree.grantorUniversity of Missouri--Columbiaeng
thesis.degree.levelDoctoraleng
thesis.degree.namePh. D.eng


Files in this item

[PDF]
[PDF]
[PDF]

This item appears in the following Collection(s)

[-] Show simple item record