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dc.contributor.advisorZaghouani, Habibeng
dc.contributor.authorEllis, Jason Scott, 1977-eng
dc.date.issued2009eng
dc.date.submitted2009 Summereng
dc.descriptionThe entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file.eng
dc.descriptionTitle from PDF of title page (University of Missouri--Columbia, viewed on January 19, 2011).eng
dc.descriptionVita.eng
dc.descriptionThesis advisor: Habib Zaghouani.eng
dc.description"July 2009"eng
dc.descriptionPh. D. University of Missouri-Columbia 2009.eng
dc.description.abstract[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Recent studies in our lab suggest that the number of divisions a naive T cell undergoes at the time of initial stimulation with antigen (Ag) affects that cell's fate as it relates to memory development. From this, it was hypothesized that the specific type of antigen presenting cell (APC) involved in the initial encounter with Ag affects the decision to become memory. To test this hypothesis, we have developed an adoptive T cell transfer model allowing us to investigate the role of specific APCs in the development of immunologic memory. Ovalbumin (OVA)- specific TCR transgenic CD4+ T cells were stimulated in vitro with Ag by purified, distinct types of APCs. These T cells were then transferred into naive mice lacking CD4+ T cells and parked for 4 mo. At this point, their memory response was analyzed upon recall with Ag. Interestingly, only B cells and CD8[alpha]+ dendritic cells (DCs) induced cells capable of inducing a strong memory cytokine response. This induction of memory was dependent on PD-L2 expression by the APCs. These findings indicate that the type of APC involved in the naive T cell's initial encounter with Ag influences the memory response.eng
dc.description.bibrefIncludes bibliographical referenceseng
dc.format.extentxi, 131 pageseng
dc.identifier.oclc698117226eng
dc.identifier.urihttps://doi.org/10.32469/10355/9741eng
dc.identifier.urihttps://hdl.handle.net/10355/9741
dc.languageEnglisheng
dc.publisherUniversity of Missouri--Columbiaeng
dc.relation.ispartofcommunityUniversity of Missouri--Columbia. Graduate School. Theses and Dissertations.eng
dc.rightsAccess is limited to the campuses of the University of Missouri.eng
dc.subject.meshCD4-Positive T-Lymphocytes -- metabolismeng
dc.subject.meshCD4-Positive T-Lymphocytes -- immunologyeng
dc.subject.meshAntigen Presenting Cells -- metabolismeng
dc.subject.meshAntigen Presenting Cells -- immunologyeng
dc.subject.meshCell Differentiation -- immunologyeng
dc.subject.meshAntigens, CD -- biosynthesiseng
dc.subject.meshImmunologic Memoryeng
dc.titleTeaching T cells to remember : the role of antigen presenting cells in the development of CD4+ T cell memoryeng
dc.typeThesiseng
thesis.degree.disciplineMicrobiology (Medicine) (MU)eng
thesis.degree.grantorUniversity of Missouri--Columbiaeng
thesis.degree.levelDoctoraleng
thesis.degree.namePh. D.eng


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