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    Coregulation of Ion Channel Conductances Preserves Output in a Computational Model of a Crustacean Cardiac Motor Neuron

    Ball, John M., 1982-
    Franklin, Clarence C.
    Tobin, Anne-Elise
    Schulz, David
    Nair, Satish S., 1960-
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    [PDF] CoregulationIonChannelConductances.pdf (428.5Kb)
    Date
    2010
    Format
    Article
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    Abstract
    Similar activity patterns at both neuron and network levels can arise from different combinations of membrane and synaptic conductance values. A strategy by which neurons may preserve their electrical output is via cell type-dependent balances of inward and outward currents. Measurements of mRNA transcripts that encode ion channel proteins within motor neurons in the crustacean cardiac ganglion recently revealed correlations between certain channel types. To determine whether balances of intrinsic currents potentially resulting from such correlations preserve certain electrical cell outputs, we developed a nominal biophysical model of the crustacean cardiac ganglion using biological data. Predictions from the nominal model showed that coregulation of ionic currents may preserve the key characteristics of motor neuron activity. We then developed a methodology of sampling a multidimensional parameter space to select an appropriate model set for meaningful comparison with variations in correlations seen in biological datasets.
    URI
    http://hdl.handle.net/10355/9761
    Citation
    Ball JM, Franklin CC, Tobin AE, Schulz DJ, Nair SS (2010) Coregulation of ion channel conductances preserves output in a computational model of a crustacean cardiac motor neuron, Journal of Neuroscience 30: 8637-8649.
    Rights
    OpenAccess.
    This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License.
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    • Biological Engineering publications (MU)
    • Electrical Engineering and Computer Science publications (MU)
    • Biological Engineering publications (MU)
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