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dc.contributor.authorBall, John M., 1982-eng
dc.contributor.authorFranklin, Clarence C.eng
dc.contributor.authorTobin, Anne-Eliseeng
dc.contributor.authorSchulz, Davideng
dc.contributor.authorNair, Satish S., 1960-eng
dc.date.issued2010-06eng
dc.descriptionThis item also falls under Society for Neuroscience copyright. For more information, please visit http://www.jneurosci.org/cgi/content/full/30/25/8637?maxtoshow=&hits=10&RESULTFORMAT=1&author1=nair&andorexacttitle=and&andorexacttitleabs=and&andorexactfulltext=and&searchid=1&FIRSTINDEX=0&sortspec=relevance&resourcetype=HWCIT&eaf . Link active as of 1/29/2011. Link maintenance is the responsibility of the Society for Neuroscience.eng
dc.descriptionDigital Object Identifier 10.1523/JNEUROSCI.6435-09.2010eng
dc.description.abstractSimilar activity patterns at both neuron and network levels can arise from different combinations of membrane and synaptic conductance values. A strategy by which neurons may preserve their electrical output is via cell type-dependent balances of inward and outward currents. Measurements of mRNA transcripts that encode ion channel proteins within motor neurons in the crustacean cardiac ganglion recently revealed correlations between certain channel types. To determine whether balances of intrinsic currents potentially resulting from such correlations preserve certain electrical cell outputs, we developed a nominal biophysical model of the crustacean cardiac ganglion using biological data. Predictions from the nominal model showed that coregulation of ionic currents may preserve the key characteristics of motor neuron activity. We then developed a methodology of sampling a multidimensional parameter space to select an appropriate model set for meaningful comparison with variations in correlations seen in biological datasets.eng
dc.identifier.citationBall JM, Franklin CC, Tobin AE, Schulz DJ, Nair SS (2010) Coregulation of ion channel conductances preserves output in a computational model of a crustacean cardiac motor neuron, Journal of Neuroscience 30: 8637-8649.eng
dc.identifier.issn0270-6474/10/308637eng
dc.identifier.urihttp://hdl.handle.net/10355/9761eng
dc.publisherSociety for Neuroscienceeng
dc.relation.ispartofcollectionElectrical and Computer Engineering Publications (MU)eng
dc.relation.ispartofcommunityUniversity of Missouri-Columbia. College of Engineering. Department of Electrical and Computer Engineeringeng
dc.source.harvestedMU Computational Neurobiology Center Web site.eng
dc.subject.lcshVariation (Biology)eng
dc.subject.lcshCrustacea -- Nervous systemeng
dc.subject.lcshIon channelseng
dc.titleCoregulation of Ion Channel Conductances Preserves Output in a Computational Model of a Crustacean Cardiac Motor Neuroneng
dc.typeArticleeng


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