Coregulation of Ion Channel Conductances Preserves Output in a Computational Model of a Crustacean Cardiac Motor Neuron

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Coregulation of Ion Channel Conductances Preserves Output in a Computational Model of a Crustacean Cardiac Motor Neuron

Please use this identifier to cite or link to this item: http://hdl.handle.net/10355/9761

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dc.contributor.author Ball, John M., 1982-
dc.contributor.author Franklin, Clarence C.
dc.contributor.author Tobin, Anne-Elise
dc.contributor.author Schulz, David
dc.contributor.author Nair, Satish S., 1960-
dc.date.accessioned 2011-01-27T22:49:18Z
dc.date.available 2011-01-27T22:49:18Z
dc.date.issued 2010-06-23
dc.identifier.citation Ball JM, Franklin CC, Tobin AE, Schulz DJ, Nair SS (2010) Coregulation of ion channel conductances preserves output in a computational model of a crustacean cardiac motor neuron, Journal of Neuroscience 30: 8637-8649. en_US
dc.identifier.issn 0270-6474/10/308637
dc.identifier.uri http://hdl.handle.net/10355/9761
dc.description This item also falls under Society for Neuroscience copyright. For more information, please visit http://www.jneurosci.org/cgi/content/full/30/25/8637?maxtoshow=&hits=10&RESULTFORMAT=1&author1=nair&andorexacttitle=and&andorexacttitleabs=and&andorexactfulltext=and&searchid=1&FIRSTINDEX=0&sortspec=relevance&resourcetype=HWCIT&eaf . Link active as of 1/29/2011. Link maintenance is the responsibility of the Society for Neuroscience. en_US
dc.description Digital Object Identifier 10.1523/JNEUROSCI.6435-09.2010
dc.description.abstract Similar activity patterns at both neuron and network levels can arise from different combinations of membrane and synaptic conductance values. A strategy by which neurons may preserve their electrical output is via cell type-dependent balances of inward and outward currents. Measurements of mRNA transcripts that encode ion channel proteins within motor neurons in the crustacean cardiac ganglion recently revealed correlations between certain channel types. To determine whether balances of intrinsic currents potentially resulting from such correlations preserve certain electrical cell outputs, we developed a nominal biophysical model of the crustacean cardiac ganglion using biological data. Predictions from the nominal model showed that coregulation of ionic currents may preserve the key characteristics of motor neuron activity. We then developed a methodology of sampling a multidimensional parameter space to select an appropriate model set for meaningful comparison with variations in correlations seen in biological datasets. en_US
dc.language.iso en_US en_US
dc.publisher Society for Neuroscience en_US
dc.subject.lcsh Variation (Biology) en_US
dc.subject.lcsh Crustacea -- Nervous system en_US
dc.subject.lcsh Ion channels en_US
dc.title Coregulation of Ion Channel Conductances Preserves Output in a Computational Model of a Crustacean Cardiac Motor Neuron en_US
dc.type Article en_US
dc.source.harvested MU Computational Neurobiology Center Web site. en_US
dc.relation.ispartofcommunity University of Missouri-Columbia. College of Engineering. Department of Electrical and Computer Engineering
dc.relation.ispartofcollection Electrical and Computer Engineering Publications (MU)


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