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    Novel compounds to treat urinary tract infection [abstract]

    Hultgren, Scott
    Almqvist, Fred
    Janetka, Jim
    Pinkner, Jerry
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    [PDF] NovelCompoundsTreat[abstract].pdf (48.56Kb)
    Date
    2010-10
    Format
    Abstract
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    Abstract
    Urinary tract infections (UTI) affect a large proportion of the population and account for significant morbidity and high medical costs. Uropathogenic Escherichia coli (UPEC) is responsible for up to 85% of infections and a large percentage of recurrent UTI are caused by the same strain of bacteria as the initial UTI despite the antibiotic regimen; the current gold standard. The annual UTI incidence rate is 12.1% in women and 3% among men. Recurrence rates are high with women having a 25% to 44% chance of developing a second episode within 6 months of the initial UTI. Treatment of UTI like other microbial infections is exacerbated by increasing antimicrobial resistance and there is a huge unmet need for alternative therapies. Novel patented compounds such as Pilicides and Mannosides disrupt pili biogenesis and host-pathogen interaction to effectively block disease progression. Potential Areas of Applications: * Urinary tract Infections
    URI
    http://hdl.handle.net/10355/9771
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