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dc.contributor.advisorLysen, John C.eng
dc.contributor.authorPurdy, Alan Harriseng
dc.date.issued1970eng
dc.descriptionIncludes vita.eng
dc.description.abstractThis dissertation deals with the problem of quantification of the properties and activities of living tissue in the peripheral vasculature. The method of quantification is lumped hydraulic impedance analysis. The object of this study is to show that the mammalian peripheral vasculature, specifically the dog's kidney, meets the conditions necessary for lumped hydraulic impedance analysis. This is an experimental and theoretical study to demonstrate that the relationship between blood pressure and flow is linear and that the physical size of the vasculature involved is small enough to meet the requirements of the lumping theory. The experimental method used is the injection of hydraulic sine waves into the blood flow system of the dog's kidney. By this means, two proofs of linearity were derived. One method of proof was to examine the pressure flow relationships of the blood by means of cross correlation. The other means was to compare the velocities of the pulse waves of different mean blood pressures. Pulse wave velocities were also measured as a means of demonstrating the length of the system with respect to the wave length and thus show the degree of lumping. The theoretical chapter of the dissertation demonstrates the necessity of the complex relationship between pressure and flow being a constant, i.e., linear. The meaning of the lumped hydraulic impedance as applied to the vasculature is also explained. The newly observed facts in this investigation show: (1) the relationship between pressure and flow of blood in the dog's kidney is linear as shown by a mean cross-correlation coefficient of .9792. (2) the physical length of the vascular bed of the kidney is shown to be small enough with respect to the pulse wave length to apply lumped hydraulic analysis with an error of less than 6.5% to quantify the following properties: A. Pulsatile resistance. B. Total reactance. C. Inertance reactance. D. Compliance reactance. E. Lumped depth of wave penetration. F. Lumped vessel radius. G. Pulsatile real work. H. Pulsatile reactive work.eng
dc.description.bibrefIncludes bibliographical references.eng
dc.format.extentvi, 91 pages : illustrationseng
dc.identifier.urihttps://hdl.handle.net/10355/97888
dc.languageEnglisheng
dc.publisherUniversity of Missouri--Columbiaeng
dc.relation.ispartofcommunityUniversity of Missouri--Columbia. Graduate School. Theses and Dissertationseng
dc.rightsOpenAccess.eng
dc.rights.licenseThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License.
dc.sourceDigitized a department copy.eng
dc.titleInvestigation of the pressure-flow relationships of blood in the mammalian kidneyeng
dc.typeThesiseng
thesis.degree.disciplineMechanical and aerospace engineering (MU)eng
thesis.degree.grantorUniversity of Missouri--Columbiaeng
thesis.degree.levelDoctoraleng
thesis.degree.namePh. D.eng


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