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dc.contributor.advisorKirk, Mark D.eng
dc.contributor.advisorShi, Huidong, Ph. D.eng
dc.contributor.authorRath, Prakash, 1979-eng
dc.date.issued2009eng
dc.date.submitted2009 Falleng
dc.descriptionThe entire thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file; a non-technical public abstract appears in the public.pdf file.eng
dc.descriptionTitle from PDF of title page (University of Missouri--Columbia, viewed on January 27, 2011).eng
dc.descriptionThesis advisor: Dr. Mark Kirk and Dr. Huidong Shi.eng
dc.descriptionVita.eng
dc.descriptionPh. D. University of Missouri--Columbia, 2009.eng
dc.description.abstractStem cells have the unique ability to differentiate into the many specialized cells of the body. During adulthood, stem cells remain in the organism and maintain the ability to repair and replenish injured or dead cells when necessary. In some cancers however, stem cells are implicated as the driving force of tumorigenesis. The cancer stem cell (CSC) hypothesis states that only a small fraction of cells within a tumor has the capacity to regenerate and maintain the heterogeneity seen in the tumor they were derived from. Cancer stem cells were first identified as being associated with acute myeloid leukemia model 15 years ago, and since then, have been detected in a variety of tumors. In malignant gliomas such as glioblastoma multiforme (GBM), a GBM-CSC population with increased levels of resistant to chemotherapy and radiation therapy is thought to be responsible for malignancy and tumor recurrence. To test the CSC hypothesis, it is necessary to identify these cells. If the model proves to be valid, developing CSC specific therapies would target the root of cancer growth. Overall, understanding the cells involved in brain tumor development, dispersal, and prevention, is the focus of this dissertation.eng
dc.description.bibrefIncludes bibliographical references.eng
dc.format.extentviii, 161 pageseng
dc.identifier.oclc698668856eng
dc.identifier.urihttps://doi.org/10.32469/10355/9863eng
dc.identifier.urihttps://hdl.handle.net/10355/9863
dc.languageEnglisheng
dc.publisherUniversity of Missouri--Columbiaeng
dc.relation.ispartofcommunityUniversity of Missouri--Columbia. Graduate School. Theses and Dissertationseng
dc.rightsOpenAccess.eng
dc.rights.licenseThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License.
dc.sourceSubmitted by University of Missouri--Columbia Graduate School.eng
dc.subject.lcshBrain -- Tumorseng
dc.subject.lcshBrain -- Cancer -- Etiologyeng
dc.subject.lcshCancer cellseng
dc.subject.lcshStem cellseng
dc.subject.lcshCarcinogenesiseng
dc.titleTumor-initiating cells in malignant brain tumorseng
dc.typeThesiseng
thesis.degree.disciplineBiological sciences (MU)eng
thesis.degree.grantorUniversity of Missouri--Columbiaeng
thesis.degree.levelDoctoraleng
thesis.degree.namePh. D.eng


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