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    • 2009 Dissertations (MU)
    • 2009 MU dissertations - Freely available online
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    Innate immunity in Arabidopsis : molecular mechanisms of HOPA1 and AVRRS4 - specific disease resistance signaling pathways

    Kim, Sang Hee, 1975-
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    Date
    2009
    Format
    Thesis
    Metadata
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    Abstract
    Plants have evolved several layers of predetermined defenses, collectively called the innate immune system. Because of its effectiveness effector-triggered immunity (ETI) is a highly valuable agronomic trait. However, ETI has the potential to be highly deleterious to the host and needs to be tightly controlled. To understand the molecular basis for ETI, I used genetic approaches. Using a loss of resistance screen, I cloned the hopA1-specific RPS6 (Resistance to Pseudomonas syringae 6) resistance gene. Using a gain of resistance screen, we cloned SRFR1 (Suppressor of RPS4-RLD), which reactivates avrRps4- and hopA1-triggered immunity. Based on the genetic, molecular, biochemical, and phylogenic evidence, we propose that SRFR1 functions in a transcriptional repressor complex that balances plant immunity and development. To date RPS4 and RPS6 are the only Arabidopsis TIR-NBS-LRR resistance genes for which P. syringae effectors are known. Both pathways are negatively regulated by SRFR1. Functional characterization of RPS6 and SRFR1 will provide an important piece of the ETI puzzle.
    URI
    https://doi.org/10.32469/10355/9865
    https://hdl.handle.net/10355/9865
    Degree
    Ph. D.
    Thesis Department
    Plant sciences (MU)
    Rights
    OpenAccess.
    This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License.
    Collections
    • 2009 MU dissertations - Freely available online
    • Plant Sciences electronic theses and dissertations (MU)

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