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    • University of Missouri-Columbia
    • Graduate School - MU Theses and Dissertations (MU)
    • Theses and Dissertations (MU)
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    • 2009 Dissertations (MU)
    • 2009 MU dissertations - Freely available online
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    Computational modeling of the fear circuit : a system approach to understand anxiety and stress disorder

    Li, Guoshi
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    [PDF] research.pdf (2.989Mb)
    Date
    2009
    Format
    Thesis
    Metadata
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    Abstract
    Computational models are becoming increasingly important to systems neuroscience. In fear learning, although there have been a few attempts at modeling emotional learning and memory in the past, most were limited to simplified connectionist or artificial neural network models which did not incorporate current knowledge about the biophysical properties of accurate neurons. This research focused on extending our understanding of the neural mechanisms underlying fear learning and extinction using biophysically realistic network models. Since disruptionof the fear circuit is thought to underlie the pathology of post traumatic stress (PTSD)and other anxiety disorders, such models could potentially provide ideas and approaches for the development of new medications.We initiated modeling of the overall fear circuit starting with the most critical component, the lateral amygdala (LA), and attempted todescribe how a single structure (i.e., LA) can encode both acquisition and extinctionmemories learned during auditory fear ditioning. Next, we developed a biophysical model of another critical element of the fear circuit, the ITC (intercalated cells) to understand the role of ITC neurons in suppressing fear. After successful development ofcomponent model for the LA and ITC network, an overall amygdala network model was developed to investigate how conditioning-induced potentiation of LA response leadst o activation of the central amgyala (CE) output, by inclusion of another important unit ofthe circuit - basal amydala (BA).
    URI
    https://hdl.handle.net/10355/9875
    https://doi.org/10.32469/10355/9875
    Degree
    Ph. D.
    Thesis Department
    Electrical and computer engineering (MU)
    Rights
    OpenAccess.
    This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License.
    Collections
    • 2009 MU dissertations - Freely available online
    • Electrical Engineering and Computer Science electronic theses and dissertations (MU)

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